Which of the following is NOT an antistaphylococcal penicillin?

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Multiple Choice

Which of the following is NOT an antistaphylococcal penicillin?

Antistaphylococcal penicillins are designed to resist breakdown by staphylococcal penicillinase, the enzyme many Staphylococcus aureus produce. They achieve this with bulky side chains around the beta-lactam ring, which shields the molecule from hydrolysis. Nafcillin, oxacillin, and dicloxacillin are examples of these penicillins. Amoxicillin is an aminopenicillin that lacks that protective bulky modification, so it is susceptible to beta-lactamase and is not considered antistaphylococcal. It’s used for other infections but not reliable against penicillinase-producing Staph aureus unless combined with a beta-lactamase inhibitor.

Antistaphylococcal penicillins are designed to resist breakdown by staphylococcal penicillinase, the enzyme many Staphylococcus aureus produce. They achieve this with bulky side chains around the beta-lactam ring, which shields the molecule from hydrolysis. Nafcillin, oxacillin, and dicloxacillin are examples of these penicillins. Amoxicillin is an aminopenicillin that lacks that protective bulky modification, so it is susceptible to beta-lactamase and is not considered antistaphylococcal. It’s used for other infections but not reliable against penicillinase-producing Staph aureus unless combined with a beta-lactamase inhibitor.

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